Medical Causes of Female Sexual Dysfunction:

Vascular
High blood pressure, high cholesterol levels, diabetes, smoking, and heart disease are associated with sexual complaints in men and women. Any traumatic injury to the to the genitals or pelvic region, such as pelvic fractures, blunt trauma, surgical disruption, extensive bike riding, for instance, can result in diminished vaginal and clitoral blood flow and complaints of sexual dysfunction. Although, other underlying conditions, either psychological or physiologic may also manifest as decreased vaginal and clitoral engorgement, blood flow, or vascular insufficiency is one causal factor that should be considered.

Neurological
The same neurological disorders that cause erectile dysfunction in men can also cause sexual dysfunction in women. Spinal cord injury or disease of the central or peripheral nervous system, including diabetes, can result in female sexual dysfunction. Women with spinal cord injury have significantly more difficulty achieving orgasm than able-bodied women. The effects of specific spinal cord injuries on female sexual response is being investigated, and will hopefully lead to improved understanding of the neurological pieces of orgasm and arousal in normal women.

Hormonal/Endocrine
Dysfunction of the hypothalamic/pituitary axis, surgical or medical castration, natural menopause, premature ovarian failure, and chronic birth control pills, are the most common causes of hormonally based female sexual dysfunction. The most common complaints in this category are decreased desire and libido, vaginal dryness, and lack of sexual arousal.

Medications
Medications used to treat depression can also significantly effect the female sexual response. The most frequently used medications for uncomplicated depression are the Serotonin Re-uptake Inhibitors. Women receiving these medications often complain of decreased sexual interest.